| Scarboro | community in SW Montgomery County served by post office, 1880-1901. |
| Scarlet Ridge | N Swain County in Great Smoky Mountains National Park extending SE from Welch Ridge to Forney Creek. Near lat. 35°31'54" N., long. 83°34'40" W. |
| Scarlet Ridge Creek | rises in N Swain County in Great Smoky Mountains National Park and flows SE into Jonas Creek. |
| Schenck Forest | See Carl Alwin Schenck Forest. |
| Schencks Station | community in S Cleveland County. |
| Schene Wolf Creek | rises near Organ and Lower Stone Churches approx. 5 mi. SW of Rockwell, SE Rowan County, and flows S into NE Cabarrus County, where it enters Dutch Buffalo Creek. Probably named by early German settlers, Schene being derived from schön (beautiful). Sometimes also called Jennie Wolf Creek. |
| Schley | community in E Orange County served by post office, 1898-1907. |
| Schlosstown | community in N Franklin County. Known locally as "Slosh." |
| Scholl | community in W Scotland County. |
| School House Branch | rises in W Carteret County and flows SW into Hadnot Creek. |