| Osage Mountain | S Macon County between West Fork Overflow Creek and Watkins Creek. |
| Osborn Branch | rises in NE Transylvania County and flows SE into Boylston Creek. |
| Osborn Mountain | E Watauga County between Elk Creek and Southwest Stony Fork Creek. |
| Osborne | community in S Richmond County. |
| Osborne Creek | rises in SE Wilkes County and flows S into Iredell County, where it enters Hunting Creek. |
| Osbornville | community in SE Wilkes County on Osborne Creek. |
| Osburn Ford | shallows in Pigeon River just NE of the town of Clyde in central Haywood County. |
| Osceola | community in central Alamance County served by post office, 1894-1903. |
| Osceola | crossroads community in NE Guilford County. |
| Osceola Lake | central Henderson County, is fed by Findley, Perry, and Tonys Creeks and drained by Shephard Creek. It was formed about 1914 and named for an Indian chief in the area. Covers 12 acres; max. depth 20 ft. |