| Orfords Pond | See Sunset Lake. |
| Organ Church | community in S Rowan County served by post office, 1851-1906. |
| Oriental | town in S Pamlico County on Neuse River at the mouth of Smith Creek. First settled about 1870 by "Uncle Lou" Midgett and known as Smith's Creek. Later renamed for the Federal transport Oriental, which sank in 1862 near Bodie Island. The ship's nameplate had been found by Rebecca Midgett, wife of the town's first settler. |
| Orinoco | community in NE Davidson County served by post office, 1886-1904. |
| Orion | community in SE Ashe County. |
| Orlando | community in S Macon County. |
| Orleans | community in SW Lincoln County served by post office, 1886-1906. |
| Ormonds Township | SE Greene County. Named for the Ormond family, which settled in the Ormondsville community prior to 1769. |
| Ormondsville | community in E Greene County. Developed from a country crossroads store at the Ormond family plantation. |
| Orris's Run | swampy stream rises in N central Beaufort County and flows SE into Pungo Creek. Named for Orris Waters who lived nearby. |